The nanomaterial has admired qualities to equilibrate boss components which pick biocatalysts proficiency, including a particular surface territory, mass exchange confirmation and productive compound stacking. This review displays the current circumstance and frameworks in compound immobilization. A couple of methods are used which are capable to join proteins/synthetic substances with nanoparticles. Immobilization process is to overhaul the operational execution of an impetus for mechanical applications. So far different cross sections have been portrayed in the written work to improve the execution of the immobilized proteins. With the incident to nanotechnology, the nanomaterial due to their one of a kind physical - substance properties constitute novel and charming frameworks for compound immobilization.